Discussion about this post

User's avatar
HeldFast's avatar

IgG4 is very bad news! "IgG4-related disease (IgG4-RD) is considered a systemic, chronic, and inflammatory disorder that is characterized by the enlargement of involved organs, elevated levels of IgG4, and abundant infiltration of plasmacytes with IgG4 and fibrosis in involved organs. "

https://pubmed.ncbi.nlm.nih.gov/21894525/

"IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it is unsurprising that IgG4 has been implicated in certain tumor types. "

https://pubmed.ncbi.nlm.nih.gov/26742760/

Expand full comment
Ryan Oreily's avatar

I was wondering where Igor was, I felt a little like I was walking alone in the dark, without Igor and jikky on Twitter. Vanden Bossche came in to fill the gap… man, it’s all like a well oiled machine… if people only opened their eyes, or stop letting amateurs “drive the car”

Thank you, dear brother.

Expand full comment
497 more comments...

No posts

Ready for more?