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HeldFast's avatar

IgG4 is very bad news! "IgG4-related disease (IgG4-RD) is considered a systemic, chronic, and inflammatory disorder that is characterized by the enlargement of involved organs, elevated levels of IgG4, and abundant infiltration of plasmacytes with IgG4 and fibrosis in involved organs. "

https://pubmed.ncbi.nlm.nih.gov/21894525/

"IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and inflammation. Since the immune system is exposed to tumor-associated antigens over a relatively long period of time, and tumors notoriously promote inflammation, it is unsurprising that IgG4 has been implicated in certain tumor types. "

https://pubmed.ncbi.nlm.nih.gov/26742760/

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NarcoPacifist's avatar

I was wondering where Igor was, I felt a little like I was walking alone in the dark, without Igor and jikky on Twitter. Vanden Bossche came in to fill the gap… man, it’s all like a well oiled machine… if people only opened their eyes, or stop letting amateurs “drive the car”

Thank you, dear brother.

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