My general intuition for what it's worth is that based on the following premises it looks like some degree of permanence likely, but the insane magnitude & sudden onset of #'s feels kind of bizarre - where's the general carnage that should go along with this even in regular ppl's anecdotal exp (#6 below is a bit of a contradiction to thi…
My general intuition for what it's worth is that based on the following premises it looks like some degree of permanence likely, but the insane magnitude & sudden onset of #'s feels kind of bizarre - where's the general carnage that should go along with this even in regular ppl's anecdotal exp (#6 below is a bit of a contradiction to this) - which suggests maybe you're right about transitory nature (almost as though everyone went on birth control for a few months at the same time?):
1. Ovarian tissues - particularly follicles/eggs - have lots of one-and-done cells
2. Ovarian tissue is overly susceptible to small changes in bioenvironment compared to most other tissues
3. Menses getting 'thrown off' by something would more likely than not impact cellular pathways/chemistry that includes eggs etc., especially considering that loss of period means that the normal chemistry etc. that regulates egg release/ovulation etc. was definitely tampered with somehow.
4. One of the most likely culprit physiological 'insults' (academic language is so awesome) is LNP mediated inflammation (bec LNP distribution + known toxicities), even if inflammation is transitory, damage it leaves behind esp if it hits the more sensitive tissues in ovaries would likely be less so if not permanent (like myo) (even if it only screws up directly something that itself can recover, what if the 'something' itself is part of hormones/chemistry that affects eggs/follicles so while it was in a damaged state it monkeyed around with things that are less susceptible to recovering, I'm no expert on ovarian function but my general impression is that there is lots of highly sensitive 'stuff' going on behind the blood barrier there, maybe someone like Thorpe could shed light here.)
(For the record, someone came to me for help trying to find them someone who can treat towards the end of 2021, had lost period since J&J shot around March or April don't remember which, no LNP's there)
5. Ditto for spike protein mediated damage
6. The sheer #'s feel like there would be a range of pathological manifestation & severity & etiology even, so some % would probably have to be as you put it more like inflation ;) (Someone needs to make a meme to the effect of "inflation is inflammation in the economy")
If the ICD or other pop level surveillance data would not reflect anything than that would be a solid indication that you're probably right about it being a temp blip.
My general intuition for what it's worth is that based on the following premises it looks like some degree of permanence likely, but the insane magnitude & sudden onset of #'s feels kind of bizarre - where's the general carnage that should go along with this even in regular ppl's anecdotal exp (#6 below is a bit of a contradiction to this) - which suggests maybe you're right about transitory nature (almost as though everyone went on birth control for a few months at the same time?):
1. Ovarian tissues - particularly follicles/eggs - have lots of one-and-done cells
2. Ovarian tissue is overly susceptible to small changes in bioenvironment compared to most other tissues
3. Menses getting 'thrown off' by something would more likely than not impact cellular pathways/chemistry that includes eggs etc., especially considering that loss of period means that the normal chemistry etc. that regulates egg release/ovulation etc. was definitely tampered with somehow.
4. One of the most likely culprit physiological 'insults' (academic language is so awesome) is LNP mediated inflammation (bec LNP distribution + known toxicities), even if inflammation is transitory, damage it leaves behind esp if it hits the more sensitive tissues in ovaries would likely be less so if not permanent (like myo) (even if it only screws up directly something that itself can recover, what if the 'something' itself is part of hormones/chemistry that affects eggs/follicles so while it was in a damaged state it monkeyed around with things that are less susceptible to recovering, I'm no expert on ovarian function but my general impression is that there is lots of highly sensitive 'stuff' going on behind the blood barrier there, maybe someone like Thorpe could shed light here.)
(For the record, someone came to me for help trying to find them someone who can treat towards the end of 2021, had lost period since J&J shot around March or April don't remember which, no LNP's there)
5. Ditto for spike protein mediated damage
6. The sheer #'s feel like there would be a range of pathological manifestation & severity & etiology even, so some % would probably have to be as you put it more like inflation ;) (Someone needs to make a meme to the effect of "inflation is inflammation in the economy")
If the ICD or other pop level surveillance data would not reflect anything than that would be a solid indication that you're probably right about it being a temp blip.