Following up, there is little interest in the effects of maternal auto-antibodies except in the case of lupus (maternal) and autism (offspring), and almost no animal research to back up these theories that I can find. It does seem that in the case of lupus the cardiac abnormalities should manifest before birth; though there's a question …
Following up, there is little interest in the effects of maternal auto-antibodies except in the case of lupus (maternal) and autism (offspring), and almost no animal research to back up these theories that I can find. It does seem that in the case of lupus the cardiac abnormalities should manifest before birth; though there's a question of how little screening is done for the cases in India.
So generally maternal-antibody-mediated auto-immunity is not a thing that seems to happen. Possibly thanks to pregnancy modulating / tempering immune responses in general (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709983/) - but there could even be some way the immune system regains self-tolerance competency that it doesn't have normally, and selectively avoids auto-immunity.
So I still don't find the auto-antibodies theory compelling.
Following up, there is little interest in the effects of maternal auto-antibodies except in the case of lupus (maternal) and autism (offspring), and almost no animal research to back up these theories that I can find. It does seem that in the case of lupus the cardiac abnormalities should manifest before birth; though there's a question of how little screening is done for the cases in India.
So generally maternal-antibody-mediated auto-immunity is not a thing that seems to happen. Possibly thanks to pregnancy modulating / tempering immune responses in general (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709983/) - but there could even be some way the immune system regains self-tolerance competency that it doesn't have normally, and selectively avoids auto-immunity.
So I still don't find the auto-antibodies theory compelling.