Infections based on what? A DNA strand or some NEW symptoms?
Dr. Kary Mullis, inventor of the PCR test stated that his test only idents strands of DNA from Hep. and various Flus, and that the test was NEVER intended to be used as a diagnostic tool.
US Dr. Elisabeth Eads studies noted that the PCR test gives 97% false positives. The quick a…
Infections based on what? A DNA strand or some NEW symptoms?
Dr. Kary Mullis, inventor of the PCR test stated that his test only idents strands of DNA from Hep. and various Flus, and that the test was NEVER intended to be used as a diagnostic tool.
US Dr. Elisabeth Eads studies noted that the PCR test gives 97% false positives. The quick antigen test gives a 40% false negative! (Danish Manufacturer). 3 rapid test kits have Sodium azide, a chemical is found in herbicides and, pest control agents,
NOTE!! The WHO on Jan. 20, 2021 in their Directive #202005 stated that the PCR test is of NO VALUE.. this superseding their Jan.20.2020 advice to do PCR test.
FDA, CDC halt PCR “test”emergency use authorization on December 31, 2021 after admitting it cannot distinguish between COVID and flu.
As well as SinoVac, instead of inventing a new variant, what about the EFFECTS of AZ, loaded with..
Video: Graphene Oxide: A Toxic Substance in the Vial of the COVID-19 mRNA Vaccine? By Ricardo Delgado and Prof Michel Chossudovsky Global Research, January 19, 2022.
Dr. Vladimir Zelenko. The mRNA injections HAVE AIDS!
Swedish study 2.28.22 demonstrated and confirmed that the mRNA in the Pfizer/BioNTech Covid injections infiltrate cells and transcribes its message onto human DNA within 6 hours, altering our own DNA
Dr. Sucharit Bhakdi, Autopsies Prove Vax BioWeapon Caused Autoimmune Attacks And Death. (Based on 70 autopsies done by Germany's top pathologist, Prof. Dr. Arne Burkhardt).
Austrian graphene Research Scientist/Med. Dr. Andreas Noack was MURDERED after he released his evidence of graphene in the 4 mRNA injections, and describing it as ''razor blades in the blood that will kill all who get it''.
Prof Igor Chudov Pfizer vaccine, taken once, permanently changes the DNA of affected cells…DNA transcribed from Pfizer mRNA Vaccine contains mutant gp130 Cancer Cells. 28,2,22
Jourrnal of Hepatology. Immune-mediated hepatitis with the Moderna vaccine.. confirmed.
Brghteon. Dr. Jane Ruby Show. Incredible evidence of cancer diagnoses in the jabbed, exploding cancers in the boosted. 2.15.22.
Zelenko, in the recent X22 video (in the clip that I saw), did not say that vaccinated people get the "AIDS virus" known as "HIV" from the vaccine. AIDS is a disease, it is a list of symptoms. AIDS is often, but not always, supposedly caused by infection with the virus HIV. Zelenko in fact said something like (from my memory) "Let me be very careful with my words...." before describing how the Covid Vax can generate AIDS-like symptoms [in at least some people].
Thank you. I enjoyed the clip; I didn't see it before.
At Aprox 1min 27 sec: Zelenko says "....not HIV-induced AIDS....".
In other words, not all AIDS is "HIV-induced AIDS", thus not exactly identical to the disease first discovered in gays, drug addicts, and people with blood transfusions.
I am being picky ....
.....because under certain conditions "HIV-induced AIDS" is contagious while "Vaccine-induced AIDS" is not contagious.
There are suggestions that Spike can be shed from the vaccinated, but shed Spike doesn't reproduce in an unvaccinated person. You may have a chain of transfer (vax to unvax to unvax) if you don't take a bath, don't shower, or don't wash your hands but even under unsanitary conditions the chain will dilute itself out rather fast. In contrast, the virus HIV can infect one person, that person can infect another, the second can infect a third, and the chain of transfer can be quite long.
At the end, Zelenko says "....I just like 'AIDS' because it freaks the hell out of people...makes them think....". This isn't dishonest, because he does define the terms.
Fauci apparently used the”Key HIV Component” in COVID-19.
And a group of honest Medical Scientists in India found it! That’s right, autoimmune disease can be caused by HIV. And HIV, can cause a lot of other problems.
Note: this review was so important, they forced the team to withdraw it. Later, one of the team members admitted it, in writing.
Fauci Hold Patents on a Key HIV Component Used to Create COVID-19
By Dr. Jerome Corsi| April 28th, 2020
Why does Dr. Anthony Fauci's name appear on 4 U.S. patents for a key glycoprotein that appears to have been inserted into a SARS virus chassis to create the current COVID-19 epidemic?
The legal portal Justia.com lists the following "patents by inventor Anthony S. Fauci" involving a glycoprotein found in the HIV-1, a disease that attacks the human immune system, leading to the Acquired Immune Deficiency Syndrome, more commonly known as AIDS. In 1990, Fauci held the same position at the NIH that he holds today. Fauci made his mark around the anti-viral medications that were developed by Big Pharma to combat the AIDS epidemic raging at that time.
This same glycoprotein, identified as Glycoprotein 120, or simply as GP120, has also been found to be a key component of the current COVID-19, a disease that appears to combine a HIV-1 attack on the human immune system, with SARS CoV-1, the pathogen from the original SARS ("Severe Acute Respiratory System") that created an international pandemic in 2002-2003. The pathogen in COVID-19 is named SARS CoV-2 in medical scientific literature.
The four patents on which Fauci is named as an inventor are the following:
Patent Number: 9896509, patent granted August 3, 2016. "Use of antagonists of the interaction between HIV120 and ?4?7 integrin.
Publication Number: 20160333309, patent application filed August 3, 2016. "Use of Antagonists of the Interaction Between HIV GP120 and A4B7 Integrin.
Patent Number: 9441041, patent granted September 13, 2016. "Use of antagonists between HIV GP120 and ?4?7 integrin."
Publication Number 2016007586, patent application filed September 21, 2015. "Use of antagonists of the Interaction Between HIV GP120 and A4B7 Integrin."
An article published by a group of medical scientists in India in the medical science journal BioRXiv in January 2020 was entitled "Uncanny similarity of unique inserts in the 2019-nCov spike protein to HIV-1 and Gag."
In a highly controversial finding, the medical scientists in India reported: "We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-Gag, all of which have identity/similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature."
The article almost immediately was withdrawn after disinformation experts recognized the medical scientists in India were suggesting that COVID-19 was created by inserting the particular glycoprotein from the HIV-1 disease that involve patents held by or applied for by Fauci. Even more upsetting to disinformation operatives was the suggestion that the insertion of these 4 inserts into a SARS virus is not likely to occur in nature.
The clear suggestion was that COVID-19 was laboratory-created, possibly as a bioweapon, and that the creator of the virus used GP120 to do so, a glycoprotein from the HIV-1 1990s era that tied back to Fauci.
Remember the guessing games kids play... "You are getting colder"....then...."You are getting warmer!".
The evidence grows: both Covid19 infections and vaccines can cause immunosuppression. If Zelenko uses the term "AIDS" to describe "immunosupperssion", I have no problem with that but I would prefer the term "Vaccine-induced AIDS".
Now we begin to drill deeper ("you are getting warmer") , to discover exactly how Covid 19 infection or vaccination causes immunosuppression. I sometimes look at tweets by Walter Chestnut. He made a post where he said that "Spike is like a Swiss Army Knife of Death", in that the Spike protein of the Covid19 virus attacks the body in so many ways. I suspect that immunosuppression will be very complex, like a "Swiss Army Knife". The "Swiss Army Knife of Immunosuppression" has many tools, and now I drill down on just one of them.
It looks like Spike may contain four inserts from the AIDS virus, HIV. One of them is the "Furin Clevage Site". The HIV version is longer, so it may have been trimmed down to size. This overlaps with a 19 nucleotide segment that was found in a supplement to several Moderna patents, the subject of one of Igor's posts.
The other 3 come very close together in three dimensional space, in a very exposed region of Spike, as if they just stick out there at the very tip, ready to grab hold of something. Maybe something like a protein sticking out from the surface of a "CD4 Tcell", the very type of cell that HIV infects.
more to come in a couple of hours, dinner time....
They found that vaccination reduced the number of a subpopulation of CD4 Tcells among oldsters, but increased the same population among youngsters. Similar age-dependent trends for CD8 Tcells, but more variable.
This paper raises some questions. They only had a single "before" and a single "after" time point. We don't know if the collapse of Tcells recovers after several months. We don't know about other subpopulations of Tcells. I haven't seen any follow up last I looked (about 2 months ago).
Of great importance is the discovery that we need to split by age, because oldsters and youngsters had opposite results. But I see paper after paper where all the ages are pooled into a single groups!
There was one preprint that got a lot of attention, "The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses"
But what I noticed was that the data was very noisy (lots of scatter) so I wasn't impressed at all. But if they split by age, maybe the data wouldn't have been so noisy and I would be impressed.
In late May / early June 2021, a FOIA request released a lot of emails from Dr Fauci. On Feb4, 2020, Fauci received an email from [redacted]:
"...These insertions are potential CD4 binding domains (no proof yet but highly likely)...the 2019 virus could be potentially dual-targeting, infecting the lung and potentially CD4 Tcells too (like HIV..."
On the same day, Fauci replied to staff: "Please have someone respond to this person"
So on Feb4, 2020, Fauci knew that SARS2 Spike protein presented POTENTIAL risk to CD4 Tcells. I don't know what the follow up was, if any.
The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4β7 and promotes cellular activation and infection
This report describes a mechanism whereby the HIV gp120 envelope protein can deliver activating signals to CD4+ T cells. This activity may increase both productive infection in mucosal tissues around the time of transmission and the formation of viral reservoirs. gp120 mediates activating signals by binding to integrin α4β7. Antibodies specific to the V2 domain of gp120 block this interaction and may contribute to the efficacy of an HIV vaccine.
I found the Brazil preprint late Jan this year. I haven't looked at the Brazil preprint in detail yet, just a quick look. Their pdf file is large, rather jerky on my old computer. They have some structural models but they are too small, I can't tell if the HIV inserts themselves, or some other element of Spike, are binding to CD4.
I didn't know about the PNAS paper, I just downloaded it, thanks for the link. A quick look: Figs 2 & 3 don't seem to match any of the HIV sequences that were reported in SARS2.
Arms and hands of the virus grabbing onto receptors
The researchers expressed that certain proteins in HIV (gp 120) and SARS CoV-2 (S1) function the same – they are like arms and hands for the viruses to grab on to other receptors. They are also capable of crossing the blood-brain barrier and may be toxic to the brain.
HIV and coronaviruses may have a very ancient common ancestor. To me, HIV gp41+gp120 seem similar to Coronavirus Spike. They are both trimers, they are both cut by proteases that trigger changes in shape followed by membrane fusion.
Here is an examination of potential homology, with the first SARS, published long before the Covid19 pandemic.
SARS2 usually enters cells by first binding the receptor ACE2.
A chinese group examined the binding of Spike to 5054 potential human receptors (listed in a supplement). The strongest ones were then studied in the main paper.
About a month ago, I attempted to see if receptors from CD4 Tcells were among those studied. I found at least one listed in the supplement but none in the main article. Conclusion: in spite of potential HIV inserts, they do not confer strong binding to CD4 receptors. Either that, their methods were not good enough, or they lied about it. Limitations: I may have missed some CD4 receptors since I'm not an expert, and as I said, it was a month ago and my memory is dim.
I have presented just a little taste, but only from one point of view. In my mind, none of it is a "smoking gun"; it could be "probable cause" for further investigation.
I want to see structural models of HIV glycoprotein, showing that the potential inserts actually bind to human receptors.
The Indian paper observed potential HIV inserts within SARS2 but not in other coronaviruses (and they aligned the sequences of a lot of them). I want to see lots of Coronaviruses and HIV variants aligned with each other. As HIV spread among humans, it mutated, and acquired a lot of variation. Is there so much HIV variation, that I would be guaranteed to find SARS2 segments in some of them? If these potential inserts come from variable regions of HIV, we can still rescue the insertion hypothesis if these potential insertions represent the very best, or most well known, HIV strains.
After structural models, I also want to see experimental evidence these inserts within SARS2 spike actually interact with any human receptor. Finally, mutate the alleged inserts and see if they still damage Tcells.
Infections based on what? A DNA strand or some NEW symptoms?
Dr. Kary Mullis, inventor of the PCR test stated that his test only idents strands of DNA from Hep. and various Flus, and that the test was NEVER intended to be used as a diagnostic tool.
US Dr. Elisabeth Eads studies noted that the PCR test gives 97% false positives. The quick antigen test gives a 40% false negative! (Danish Manufacturer). 3 rapid test kits have Sodium azide, a chemical is found in herbicides and, pest control agents,
NOTE!! The WHO on Jan. 20, 2021 in their Directive #202005 stated that the PCR test is of NO VALUE.. this superseding their Jan.20.2020 advice to do PCR test.
FDA, CDC halt PCR “test”emergency use authorization on December 31, 2021 after admitting it cannot distinguish between COVID and flu.
As well as SinoVac, instead of inventing a new variant, what about the EFFECTS of AZ, loaded with..
Video: Graphene Oxide: A Toxic Substance in the Vial of the COVID-19 mRNA Vaccine? By Ricardo Delgado and Prof Michel Chossudovsky Global Research, January 19, 2022.
Dr. Vladimir Zelenko. The mRNA injections HAVE AIDS!
Swedish study 2.28.22 demonstrated and confirmed that the mRNA in the Pfizer/BioNTech Covid injections infiltrate cells and transcribes its message onto human DNA within 6 hours, altering our own DNA
Dr. Sucharit Bhakdi, Autopsies Prove Vax BioWeapon Caused Autoimmune Attacks And Death. (Based on 70 autopsies done by Germany's top pathologist, Prof. Dr. Arne Burkhardt).
Austrian graphene Research Scientist/Med. Dr. Andreas Noack was MURDERED after he released his evidence of graphene in the 4 mRNA injections, and describing it as ''razor blades in the blood that will kill all who get it''.
Prof Igor Chudov Pfizer vaccine, taken once, permanently changes the DNA of affected cells…DNA transcribed from Pfizer mRNA Vaccine contains mutant gp130 Cancer Cells. 28,2,22
Jourrnal of Hepatology. Immune-mediated hepatitis with the Moderna vaccine.. confirmed.
Brghteon. Dr. Jane Ruby Show. Incredible evidence of cancer diagnoses in the jabbed, exploding cancers in the boosted. 2.15.22.
This is the answer "Dr. Vladimir Zelenko. The mRNA injections HAVE AIDS!".
Once a person is infected with AIDS. Then AIDS does not need the non-vaccine to spread.
Zelenko, in the recent X22 video (in the clip that I saw), did not say that vaccinated people get the "AIDS virus" known as "HIV" from the vaccine. AIDS is a disease, it is a list of symptoms. AIDS is often, but not always, supposedly caused by infection with the virus HIV. Zelenko in fact said something like (from my memory) "Let me be very careful with my words...." before describing how the Covid Vax can generate AIDS-like symptoms [in at least some people].
Here is another one
Dr Zelenko confirms the Covid-19 Vaccines cause AIDS
https://odysee.com/@dailyexpose:1/covid-vaccines-cause-aids:3
It's in the first 3 minutes
Dr. Zelenko: Covid Jab Causes AIDS
https://odysee.com/@thedeadgene:5/drzelenkocovidjabcausesaids:2?r=4yaAzxGzG1GBCXVhS7bAX1BMGq1UTHom
Thank you. I enjoyed the clip; I didn't see it before.
At Aprox 1min 27 sec: Zelenko says "....not HIV-induced AIDS....".
In other words, not all AIDS is "HIV-induced AIDS", thus not exactly identical to the disease first discovered in gays, drug addicts, and people with blood transfusions.
I am being picky ....
.....because under certain conditions "HIV-induced AIDS" is contagious while "Vaccine-induced AIDS" is not contagious.
There are suggestions that Spike can be shed from the vaccinated, but shed Spike doesn't reproduce in an unvaccinated person. You may have a chain of transfer (vax to unvax to unvax) if you don't take a bath, don't shower, or don't wash your hands but even under unsanitary conditions the chain will dilute itself out rather fast. In contrast, the virus HIV can infect one person, that person can infect another, the second can infect a third, and the chain of transfer can be quite long.
At the end, Zelenko says "....I just like 'AIDS' because it freaks the hell out of people...makes them think....". This isn't dishonest, because he does define the terms.
You are a luck!
Fauci apparently used the”Key HIV Component” in COVID-19.
And a group of honest Medical Scientists in India found it! That’s right, autoimmune disease can be caused by HIV. And HIV, can cause a lot of other problems.
Note: this review was so important, they forced the team to withdraw it. Later, one of the team members admitted it, in writing.
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1.full.pdf
Fauci Hold Patents on a Key HIV Component Used to Create COVID-19
By Dr. Jerome Corsi| April 28th, 2020
Why does Dr. Anthony Fauci's name appear on 4 U.S. patents for a key glycoprotein that appears to have been inserted into a SARS virus chassis to create the current COVID-19 epidemic?
The legal portal Justia.com lists the following "patents by inventor Anthony S. Fauci" involving a glycoprotein found in the HIV-1, a disease that attacks the human immune system, leading to the Acquired Immune Deficiency Syndrome, more commonly known as AIDS. In 1990, Fauci held the same position at the NIH that he holds today. Fauci made his mark around the anti-viral medications that were developed by Big Pharma to combat the AIDS epidemic raging at that time.
This same glycoprotein, identified as Glycoprotein 120, or simply as GP120, has also been found to be a key component of the current COVID-19, a disease that appears to combine a HIV-1 attack on the human immune system, with SARS CoV-1, the pathogen from the original SARS ("Severe Acute Respiratory System") that created an international pandemic in 2002-2003. The pathogen in COVID-19 is named SARS CoV-2 in medical scientific literature.
The four patents on which Fauci is named as an inventor are the following:
Patent Number: 9896509, patent granted August 3, 2016. "Use of antagonists of the interaction between HIV120 and ?4?7 integrin.
Publication Number: 20160333309, patent application filed August 3, 2016. "Use of Antagonists of the Interaction Between HIV GP120 and A4B7 Integrin.
Patent Number: 9441041, patent granted September 13, 2016. "Use of antagonists between HIV GP120 and ?4?7 integrin."
Publication Number 2016007586, patent application filed September 21, 2015. "Use of antagonists of the Interaction Between HIV GP120 and A4B7 Integrin."
An article published by a group of medical scientists in India in the medical science journal BioRXiv in January 2020 was entitled "Uncanny similarity of unique inserts in the 2019-nCov spike protein to HIV-1 and Gag."
In a highly controversial finding, the medical scientists in India reported: "We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-Gag, all of which have identity/similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature."
The article almost immediately was withdrawn after disinformation experts recognized the medical scientists in India were suggesting that COVID-19 was created by inserting the particular glycoprotein from the HIV-1 disease that involve patents held by or applied for by Fauci. Even more upsetting to disinformation operatives was the suggestion that the insertion of these 4 inserts into a SARS virus is not likely to occur in nature.
The clear suggestion was that COVID-19 was laboratory-created, possibly as a bioweapon, and that the creator of the virus used GP120 to do so, a glycoprotein from the HIV-1 1990s era that tied back to Fauci.
https://sicem365.com/forums/7/topics/66481
Remember the guessing games kids play... "You are getting colder"....then...."You are getting warmer!".
The evidence grows: both Covid19 infections and vaccines can cause immunosuppression. If Zelenko uses the term "AIDS" to describe "immunosupperssion", I have no problem with that but I would prefer the term "Vaccine-induced AIDS".
Now we begin to drill deeper ("you are getting warmer") , to discover exactly how Covid 19 infection or vaccination causes immunosuppression. I sometimes look at tweets by Walter Chestnut. He made a post where he said that "Spike is like a Swiss Army Knife of Death", in that the Spike protein of the Covid19 virus attacks the body in so many ways. I suspect that immunosuppression will be very complex, like a "Swiss Army Knife". The "Swiss Army Knife of Immunosuppression" has many tools, and now I drill down on just one of them.
It looks like Spike may contain four inserts from the AIDS virus, HIV. One of them is the "Furin Clevage Site". The HIV version is longer, so it may have been trimmed down to size. This overlaps with a 19 nucleotide segment that was found in a supplement to several Moderna patents, the subject of one of Igor's posts.
The other 3 come very close together in three dimensional space, in a very exposed region of Spike, as if they just stick out there at the very tip, ready to grab hold of something. Maybe something like a protein sticking out from the surface of a "CD4 Tcell", the very type of cell that HIV infects.
more to come in a couple of hours, dinner time....
3rd of HIV deep dive:
I have been following a preprint for several months (August 2021?) that survived peer review and got into a decent journal:
https://doi.org/10.1016/j.cmi.2021.06.013
They found that vaccination reduced the number of a subpopulation of CD4 Tcells among oldsters, but increased the same population among youngsters. Similar age-dependent trends for CD8 Tcells, but more variable.
This paper raises some questions. They only had a single "before" and a single "after" time point. We don't know if the collapse of Tcells recovers after several months. We don't know about other subpopulations of Tcells. I haven't seen any follow up last I looked (about 2 months ago).
Of great importance is the discovery that we need to split by age, because oldsters and youngsters had opposite results. But I see paper after paper where all the ages are pooled into a single groups!
There was one preprint that got a lot of attention, "The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses"
https://doi.org/10.1101/2021.05.03.21256520
But what I noticed was that the data was very noisy (lots of scatter) so I wasn't impressed at all. But if they split by age, maybe the data wouldn't have been so noisy and I would be impressed.
2nd of HIV deep dive:
In late May / early June 2021, a FOIA request released a lot of emails from Dr Fauci. On Feb4, 2020, Fauci received an email from [redacted]:
"...These insertions are potential CD4 binding domains (no proof yet but highly likely)...the 2019 virus could be potentially dual-targeting, infecting the lung and potentially CD4 Tcells too (like HIV..."
On the same day, Fauci replied to staff: "Please have someone respond to this person"
So on Feb4, 2020, Fauci knew that SARS2 Spike protein presented POTENTIAL risk to CD4 Tcells. I don't know what the follow up was, if any.
SARS-CoV-2 Uses CD4 to Infect T Helper Lymphocytes
https://www.medrxiv.org/content/10.1101/2020.09.25.20200329v1.full.pdf
The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4β7 and promotes cellular activation and infection
This report describes a mechanism whereby the HIV gp120 envelope protein can deliver activating signals to CD4+ T cells. This activity may increase both productive infection in mucosal tissues around the time of transmission and the formation of viral reservoirs. gp120 mediates activating signals by binding to integrin α4β7. Antibodies specific to the V2 domain of gp120 block this interaction and may contribute to the efficacy of an HIV vaccine.
https://www.pnas.org/doi/10.1073/pnas.2011501117
I found the Brazil preprint late Jan this year. I haven't looked at the Brazil preprint in detail yet, just a quick look. Their pdf file is large, rather jerky on my old computer. They have some structural models but they are too small, I can't tell if the HIV inserts themselves, or some other element of Spike, are binding to CD4.
I didn't know about the PNAS paper, I just downloaded it, thanks for the link. A quick look: Figs 2 & 3 don't seem to match any of the HIV sequences that were reported in SARS2.
Arms and hands of the virus grabbing onto receptors
The researchers expressed that certain proteins in HIV (gp 120) and SARS CoV-2 (S1) function the same – they are like arms and hands for the viruses to grab on to other receptors. They are also capable of crossing the blood-brain barrier and may be toxic to the brain.
https://www.news24.com/health24/medical/infectious-diseases/coronavirus/more-evidence-suggesting-that-covid-19-can-enter-the-brain-20201223-2
If proteins in HIV (gp 120) and SARS CoV-2 (S1) function the same. Then are they the same?
HIV and coronaviruses may have a very ancient common ancestor. To me, HIV gp41+gp120 seem similar to Coronavirus Spike. They are both trimers, they are both cut by proteases that trigger changes in shape followed by membrane fusion.
Here is an examination of potential homology, with the first SARS, published long before the Covid19 pandemic.
https://doi:10.1016/j.theochem.2004.02.018
Are cousins the same because they all breathe and eat and share grandparents? I think that the answer is both yes and no.
5th of HIV deep dive:
https://doi.org/10.1038/s41422-021-00595-6
SARS2 usually enters cells by first binding the receptor ACE2.
A chinese group examined the binding of Spike to 5054 potential human receptors (listed in a supplement). The strongest ones were then studied in the main paper.
About a month ago, I attempted to see if receptors from CD4 Tcells were among those studied. I found at least one listed in the supplement but none in the main article. Conclusion: in spite of potential HIV inserts, they do not confer strong binding to CD4 receptors. Either that, their methods were not good enough, or they lied about it. Limitations: I may have missed some CD4 receptors since I'm not an expert, and as I said, it was a month ago and my memory is dim.
4th of HIV deep dive
I have presented just a little taste, but only from one point of view. In my mind, none of it is a "smoking gun"; it could be "probable cause" for further investigation.
I want to see structural models of HIV glycoprotein, showing that the potential inserts actually bind to human receptors.
The Indian paper observed potential HIV inserts within SARS2 but not in other coronaviruses (and they aligned the sequences of a lot of them). I want to see lots of Coronaviruses and HIV variants aligned with each other. As HIV spread among humans, it mutated, and acquired a lot of variation. Is there so much HIV variation, that I would be guaranteed to find SARS2 segments in some of them? If these potential inserts come from variable regions of HIV, we can still rescue the insertion hypothesis if these potential insertions represent the very best, or most well known, HIV strains.
After structural models, I also want to see experimental evidence these inserts within SARS2 spike actually interact with any human receptor. Finally, mutate the alleged inserts and see if they still damage Tcells.