Igor, you have to dig into the supplementary data, but if you look at eTable 3, you can find CRP data. Though the difference between treatment and control groups was not significant (p=0.20), as with the vent and mortality data, the trend was in the direction you'd expect if ivermectin had an anti-inflammatory effect. In the IVM arm, b…
Igor, you have to dig into the supplementary data, but if you look at eTable 3, you can find CRP data. Though the difference between treatment and control groups was not significant (p=0.20), as with the vent and mortality data, the trend was in the direction you'd expect if ivermectin had an anti-inflammatory effect. In the IVM arm, baseline CRP was 2.82 and ended at 3.16. While that's an increase, it was less than the control where baseline was 2.76 and increased to 3.65 on Day 5. But look also at the 95% confidence interval. The IVM arm was (-0.19 to 0.86) while the control arm was (0.22 to 1.56). In other words, some of the IVM patients saw a reduction in CRP, but the control arm patients did not (at least at the 95% C.L.). So, tighter confidence interval, lower mean, and negative lower limit indicating a reduction due to IVM. This finding supports the reduced vent and mortality data, since hyperinflammation is the root cause of most COVID deaths.
Igor, you have to dig into the supplementary data, but if you look at eTable 3, you can find CRP data. Though the difference between treatment and control groups was not significant (p=0.20), as with the vent and mortality data, the trend was in the direction you'd expect if ivermectin had an anti-inflammatory effect. In the IVM arm, baseline CRP was 2.82 and ended at 3.16. While that's an increase, it was less than the control where baseline was 2.76 and increased to 3.65 on Day 5. But look also at the 95% confidence interval. The IVM arm was (-0.19 to 0.86) while the control arm was (0.22 to 1.56). In other words, some of the IVM patients saw a reduction in CRP, but the control arm patients did not (at least at the 95% C.L.). So, tighter confidence interval, lower mean, and negative lower limit indicating a reduction due to IVM. This finding supports the reduced vent and mortality data, since hyperinflammation is the root cause of most COVID deaths.